Aleksandra Walczak (LPT ENS)

24 octobre 2016 11:30 » 12:30 — Bibliothèque PCT - F3.04

Diversity of immune repertoires

Recognition of pathogens relies on the diversity of immune receptor proteins. Recent experiments that sequence the entire immune cell repertoires provide a new opportunity for quantitative insight into naturally occurring diversity and how it is generated. I will show how by applying statistical inference to these experiments we can quantify diversity of this functional ensemble. I will discuss these results from the perspective of optimal repertoires and high throughput experiments to measure binding energies.

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