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Visualisation 4D de la vascularisation d’un rein entier obtenue grâce à la sonde multi-lentille développée dans cette étude. Les veines sont représentées en bleu et les artères en rouge. Les variations de couleur indiquent la vitesse du flux sanguin : plus la couleur est vive, plus le sang circule rapidement. Les plus petits vaisseaux font moins de 100 micromètres. ©Alexandre Dizeux
For the first time, a team of researchers [1] from the Institute of Physics for Medicine has succeeded in mapping the blood circulation of an entire organ in animals (heart, kidney and liver) with great precision in four dimensions: 3D + time. This new imaging technique, when applied to humans, could both improve our understanding of the circulatory system (veins, arteries, vessels and lymphatic system) and facilitate the diagnosis of certain blood circulation-related diseases. These results are published in Nature Communications.
Blood microcirculation is a complex network that transports blood to tissues and organs through tiny blood vessels. When this mechanism functions properly, cells receive the oxygen and nutrients they need to stay healthy, while metabolic waste is efficiently removed.
Any alteration to this network, whether structural or functional, can have serious clinical consequences, including heart failure, kidney failure and various chronic diseases. However, there is currently no imaging method that can visualise microcirculation and assess the integrity of the entire circulatory system, from the large arteries to the finest arterioles, at the level of the whole organ.
With this issue in mind, the research team at the Institute of Physics for Medicine has developed the first tool capable of producing such images [2]. This is a new type of ultrasound probe, developed as part of Nabil Haidour’s thesis work, under the supervision of Clément Papadacci. Thanks to this technology, scientists have been able to map the vascularisation and quantify the blood flow dynamics of three essential organs – the heart, kidney and liver – in animal models of comparable size to humans, all with unprecedented image resolution.
The non-invasive device made it possible to distinguish microcirculation even in the finest vessels (less than 100 micrometres). In the case of the liver, it was possible to identify and differentiate its three blood networks (arterial, venous and portal) thanks to their haemodynamic signature.
‘The originality of these results lies in the fact that these images allow us to visualise the vessels of an entire organ at very small scales (less than 100 micrometres) – this 4D image resolution is unprecedented, as is the ability to observe an entire large organ and its flow dynamics,’ explains Clément Papadacci, Inserm researcher and last author of the study.
This technology will now be tested in humans as part of a clinical trial. Developments enabling deployment in humans are being carried out with the help of ART Ultrasons biomédicaux, a technological research accelerator created by Inserm and integrated into the Institut Physique pour la médecine. ‘The probe can be connected to small portable equipment, which would allow it to be integrated into medical practice,’ explains Clément Papadacci.
"Used in clinical settings, this new technology could become a major tool for better understanding vascular dynamics as a whole, from the largest vessels to the pre-capillary arterioles. It could also help advance the diagnosis of microcirculation disorders and the monitoring of treatments for small vessel diseases, which are complex to diagnose and are diagnosed by ruling out other pathologies," concludes Clément Papadacci.
YouTube video: https://www.youtube.com/shorts/HemH8qNFozQ
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Reference:
Haidour, N., Favre, H., Mateo, P. et al. Multi-lens ultrasound arrays enable large scale three-dimensional micro-vascularisation characterisation over whole organs. Nat Commun 16, 9317 (2025).
https://doi.org/10.1038/s41467-025-64911-z
Contact:
Co-author of the study: Clément Papadacci, clement.papadacci@inserm.fr
Scientific communication at ESPCI Paris - PSL: Paul Turpault, paul.turpault@espci.fr